We observed significant association between PRS for AD risk and brain amyloidosis (PRS.R2 = 0.05, P = 2.6 × 10–85) at P-value threshold (PT) equal to genome-wide significance (PT = 5 × 10–08; Additional file 1: Fig. S18) when APOE was included. The gene discussed is APOE; the disease is Alzheimer disease.