Functional annotation by VEP [56] suggest this SNP to be a regulatory region variant for UXS1 protein coding gene, however, another nominally significant SNP, chr2q.12.2 (rs191708024, P = 1.9 × 10–04, β = 0.28, SE = 0.08, MAF = 0.01) within high LD (D’ = 1, R2 = 0.50), is an eQTL for NCK2, which is a known AD risk gene [5]. This evidence concerns the gene UXS1 and Alzheimer disease.