Two of the top CpG sites, cg00452016 and cg01667837 located in the promoter region of NNT and GPR37, respectively, are of particular interest for the multiple epigenetic regulatory features in these regions, their inverse correlations with mRNA expression in breast tumor tissues, and moreover, their putative biological functions in mediating the biological impact of SEP. This evidence concerns the gene GPR37 and breast neoplasm.