It turned out that the expressions of B3GNTL1 and HOXD8 were significantly upregulated, while the expression of remaining five genes (HOXB4, ZNF808, ITGA4, PTGER4, and HOXA7) were significantly downregulated in lung cancer tissues (p < 0.01) (Fig. 3a). This evidence concerns the gene ITGA4 and lung cancer.