SLC25A15 and Hyperornithinemia: Samples from patients under treatment, e.g. patient H (diagnosed with hyperornithinemia- hyperammonemia- homocitrullinuria (HHH) syndrome, also known as ornithine translocase (SLC25A15) deficiency) receiving citrulline, were difficult to diagnose since the framework cannot distinguish between abnormal biomarker values due to treatment or caused by the IMD.