This is reflected in the overall HRD scores (HRD-sum), where, in subtype-specific comparisons, this measure was significantly different between mutant and wild-type TP53 only in luminal A and luminal B tumours (p < 1e−5 and p = 0.005), and not in the basal-like (p = 0.126) and Her2-enriched (p = 0.254) subtypes (Fig. 1c). The gene discussed is TP53; the disease is neoplasm.