Furthermore, we also compared samples with high TP53 CCF to samples with low TP53 CCF samples (categorised according to the median value) and found that samples with high TP53 CCF have significantly higher tumour mutational burden and HRD scores in comparison to samples with low TP53 CCF and wildtype TP53 samples (Additional file 1: Fig. S3). This evidence concerns the gene TP53 and neoplasm.