We did not find germline biallelic MUTYH pathogenic variants nor did we see strong evidence for the tumor mutational signature profile, SBS18 and SBS36, that is strongly associated with germline biallelic inactivation of MUTYH gene [46] in any of the SLS tumors suggesting biallelic MUTYH inactivation is a rare cause of dMMR in SLS. Here, MUTYH is linked to neoplasm.