Notably, miR-19b-3p-enriched HMEXO and miR-19b-3p-AMEXO more effectively suppressed the expression of MMP-9 and pro-inflammatory factors in the aorta of AAA mice, suggesting that miR-19b-3p could be a potential factor in the regulation of VSMC senescence and AAA formation. Here, MMP9 is linked to triple-A syndrome.