In addition, we found that the mRNA level of pro-inflammatory factors Il6, Ccl2 and Mmp-2 in the aorta of mice was significantly downregulated by HMEXO, compared with AMEXO (Figure A similar result was obtained for MMP-9 expression in the adventitia and media of the aorta of different groups (Fig. 2D), indicating that HMEXO is more effective in reducing aortic inflammation in AAA mice than AMEXO. The gene discussed is MMP2; the disease is triple-A syndrome.