In this study, we found that compared with HMEXO, AMEXO failed to effectively inhibit SA-β-gal activity and the senescence-related protein level of p16 and p21 in senescent VSMCs and aortic tissue of Ang II-induced AAA mice, indicating impairment of the protective effects of AMEXO against VSMC senescence and AAA formation. This evidence concerns the gene AGT and triple-A syndrome.