CD8 + T cells cross-reactive to both peptides were found in three out of six non-small-cell lung cancer (NSCLC) patients [53], The commensal bacterium Bifidobacterium breve (B. breve) includes the H-2Kb–restricted SVYRYYGL peptide, which is able to elicit T cells cross-reacting with the neoepitope antigen SIYRYYGL expressed in engineered B16.SIY cell line. This evidence concerns the gene CD8A and non-small cell lung carcinoma.