Further rescue experiments showed that overexpression of DHX15 did not enhance p65 nuclear translocation when p65 was inhibited (Fig. 5B and Additional file 2: Fig. S3A, B), while lipopolysaccharide (LPS)-induced nuclear translocation of p65 was significantly rescued by downregulation of DHX15 in BC cells (Fig. 5C and Additional file 2: Fig. S3C, D). The gene discussed is RELA; the disease is breast cancer.