Furthermore, increased enrichment of terminally exhausted-like TILs was detected in NSCLC and melanoma samples with lower NEOITHS in validation datasets, whereas tumors with more heterogeneous neoantigens were enriched with activated TILs, effector/memory CD8+ T cell and progenitor CD8+ Tex (Fig. 5C). This evidence concerns the gene CD8A and non-small cell lung carcinoma.