Our analysis showed that NEO2IS correlated significantly with PDL1 and STAT3 pY705 abundance (Fig. S5d), indicating that tumor cells with more immunogenic neoantigens required an immune-suppressive microenvironment (i.e., high PDL1 expression, deregulation of molecules involved in IFN-γ signaling pathway) to survive immune cell attacks. Here, STAT3 is linked to neoplasm.