Of these seven candidate hub genes in the GSE118553 dataset, all except MAPT were significantly differentially expressed between AD and normal samples, with CASP3 and MAPK9 expressed at higher levels in normal samples and SP1, BCL2, FOXO1, and ETS1 expressed at higher levels in the AD samples (see Fig. S5). This evidence concerns the gene CASP3 and Alzheimer disease.