SP1 and early-onset autosomal dominant Alzheimer disease: These hub genes were enriched in GO annotations “Alzheimer’s disease pathway,” “Parkinson’s Disease,” “Ribosome,” and “Chronic myeloid leukemia.” In addition, 78 drugs were predicted to target FOXO1, SP1, MAPK9, and BCL2, including fluorouracil, cyclophosphamide, and epirubicin.