Mitochondria damage or nuclei damage caused by SARS-CoV-2 triggered mtDNA release or chromatin DNA shuttled from the nucleus, which led to the accumulation of cytosolic dsDNA and cGAS-mediated IFN-I signaling activation, inflammatory responses, or STING-dependent cell death.17–21 However, the antagonistic strategies of SARS-CoV-2 against cGAS signaling pathway during infection remain unknown. This evidence concerns the gene CGAS and infection.