The lowest quartile of creatinine concentration was associated with a 1.47-fold increased risk of developing diabetes compared with the high quartile (adjusted HR, 1.47; 95% CI, 1.34–1.60).Adjusted hazard ratios of model 1(age, sex) and model 2(the variables in the model I, plus body mass index,systolic blood pressure,diastolic blood pressure,fasting plasma glucose,total cholesterol,triglyceride,blood urea nitrogen,alanine aminotransferase,drinking status,smoking status and family history of diabetes) were 1.52(1.40,1.66) and 1.21(1.11,1.33), respectively, (P trend p < 0.0001). The gene discussed is GPT; the disease is diabetes mellitus.