INS and type 2 diabetes mellitus: The accumulation of metabolites (mainly diacylglycerol (DAGs))28 and a series of myoinflammatory factors29,30 (such as interleukin-631) participate in the impaired autophagy function of cells32, and then block insulin signal transduction in skeletal muscle33, and interact with each other in this process, resulting in the occurrence and progression of type 2 diabetes.