As shown in Figure 8C, CA199 expression is FITC-labeled green, CD31 expression is Alexa Fluor® 647-labeled red, through observation, we can clearly find that compared to ESM1-NC, ESM1-mimic represents colorectal cancer cells CA199 and CD31 representing blood vessels are significantly elevated (Figure 8C, 8D). The gene discussed is PECAM1; the disease is colorectal cancer.