In addition, the effect of overexpressing or silencing TUSC7 on glioma cells was revealed by wound healing and Transwell assays, and the potential mechanism by which lncRNA TUSC7 suppressed glioma progression via sponging miR-10a-5p and inhibiting brain-derived neurotrophic factor/extracellular signal-regulated kinase (BDNF/ERK) pathway was investigated, serving as the theoretical foundation and basis for research on gliomas. This evidence concerns the gene BDNF and central nervous system cancer.