ZUP1 and ovarian neoplasm: Based on their structure and underlying mechanisms, DUBs are classified into seven different families, namely, ubiquitin-specific protease, ovarian tumor (OTU) domain, Jab1/Mov34/Mpr1Pad1 N-terminal domain (JAMM [MPN]), Machado–Joseph domain (MJD [Josephin]), ubiquitin C-terminal hydrolases, zinc finger with UFM1-specific peptidase domain protein (ZUSFP/ZUP1), and motifs interacting with the novel ubiquitin-containing novel DUB family (MINDY) (Abdul Rehman et al, 2016; Haahr et al, 2018; Hermanns et al, 2018; Hewings et al, 2018; Kwasna et al, 2018; Clague et al, 2019).