At the moment, it is well established that oxidative stress plays a key role in acute neurological injuries such as prolonged seizures.[26] The inhibition of NADPH oxidase, for example, in a model of Temporal Lobe Epilepsy induced by pilocarpine, demonstrated that the free radicals produced by NADPH oxidase are involved in the neurodegeneration induced by SE and suggested therapeutic interventions aimed at inhibiting this enzyme, may present results promising.[27]. Here, FMO5 is linked to temporal lobe epilepsy.