Thus, transcriptomic analyses of temperature-switch and GCRV infection conjointly demonstrated that pro-inflammatory cytokines may be involved in temperature-dependent GCRV pathogenesis, In light of the pleiotropic roles of pro-inflammatory, pyrogenic cytokines, such as IL6, IL1β, and TNF-α, in both viral infection and temperature-related inflammation. Here, IL1B is linked to viral infectious disease.