To further dissect the role of HSP90 in viral infection, we performed a transcriptomic analysis of CIK cells treated with HSP90 specific inhibitor 17-AAG [35], we found that the transcription of membrane receptors, cell communication, cytoskeleton protein, and ion channel-related proteins were significantly downregulated when HSP90 was inhibited (Fig 4N). The gene discussed is HSP90AA1; the disease is viral infectious disease.