Besides, the transcription of Hif-1α, which is commonly related to hyperthermia and hypoxia stimulus and might be linked with the fish disease outbreak in aquaculture, remained nearly unaffected in CIK cells upon GCRV infection at different temperatures (S2G Fig), suggesting that pro-inflammatory cytokines might be the major factor involved in GCRV infection. The gene discussed is HIF1A; the disease is fish disease.