We hypothesize that polymorphisms (rs10719 and rs3742330) in DROSHA/DICER1 genes would alter these enzymes’ expression, affecting miRNA production or regulation which might affect downstream pathways related to glaucoma processes (e.g., extracellular matrix remodeling and trabecular meshwork homeostasis) and influence the disease development and progression. This evidence concerns the gene DROSHA and glaucoma.