In conclusion, our study revealed that the 3’ UTR polymorphisms, rs3742330 in DICER1 and rs10719 in DROSHA, are neither associated with POAG and PACG nor the clinical indices of glaucoma, such as IOP, cup/disc ratio, and the number of antiglaucoma medications in the Middle-Eastern cohort of Saudi Arab ethnicity. Here, DICER1 is linked to open-angle glaucoma.