TGFB1 and liver disorder: Jagged1 deficiency might also affect the transient increase in Notch1 and in the active Notch1 intracellular domain (N1ICD) necessary to induce the TGF-β1-rich primary SASP, TGF-β being an important promotor of the paracrine transmission of senescence in liver disease [6, 17, 18].