According to bioinformatics analysis (http://ubibrowser.bio-it.cn/ubibrowser/home/index), SYVN1 may be involved in the ubiquitination and degradation of FoxO1.To test this regulatory mechanism, the expression of SYVN1 and FoxO1 in HCC were examined. This evidence concerns the gene SYVN1 and hepatocellular carcinoma.