SYVN1 and hepatocellular carcinoma: In comparison with normal human liver cell line, THLE-3 cells, SYVN1 was highly expressed while FoxO1 was poorly expressed in all seven HCC cells, including HuH-6, Hep3B, Li-7, HuH-7, MHCC97H, SNU-182 and BEL-7405 cells (Fig. 1D).