Multivariate regression analysis showed that T3, T4 (P = 0.047, HR = 1.994, 95% CI 1.148 to 3.264) and N positive (P = 0.026, HR = 2.970, 95% CI 1.364 to 5.907) was independent risk factors for recurrence and metastasis of HR + /HER2 + breast cancer, while positive AR (P = 0.012, HR = 0.803, 95% CI 0.167 to 0.959) was an independent protective factor (Table 5). This evidence concerns the gene ERBB2 and breast cancer.