N positive (P = 0.024 HR = 3.139, 95% CI 1.425 to 7.034) and p53 positive (P = 0.038, HR = 2.675, 95% CI 1.037 to 5.983) were independent risk factors for recurrence and metastasis of HR + /HER2-breast cancer. This evidence concerns the gene TP53 and breast carcinoma.