TAC‐induced myocardial hypertrophy and cardiac fibrosis were also attenuated upon HIPK1 knockdown (Figure 5c,d), accompanied with reduced expression of pathological hypertrophy marker genes (ANP, BNP, and β‐MHC) and fibrosis‐associated genes (Col1a1, Col3a1, and CTGF) (Figure 5e,f). This evidence concerns the gene CCN2 and cardiac hypertrophy.