To assess whether the CREB‐C/EBPβ axis contributes to the functional role of HIPK1 in pathological cardiac hypertrophy, we co‐treated NRCMs with sh‐HIPK1 and OE‐CREB (or OE‐C/EBPβ) vectors upon PE stress. This evidence concerns the gene CREB1 and cardiac hypertrophy.