HIPK1 functions as a serine/threonine‐protein kinase and localizes predominantly in the nucleus.[11] HIPK1 was previously reported to induce phosphorylation of the CREB, which is a critical transcription factor that can activate C/EBPβ transcription.[20, 21] Moreover, activated C/EBPβ is involved in pathological cardiac hypertrophy.[21] To elucidate the mechanism by which HIPK1 regulates pathological cardiac hypertrophy, we first determined HIPK1 expression in PE‐stressed NRCMs. The gene discussed is CREB1; the disease is cardiac hypertrophy.