Interestingly, we found that HIPK1+/− mice were also resistant to pathological cardiac hypertrophy and cardiac dysfunction accompanied with an inhibition of the CREB‐C/EBPβ axis (Figures S13–S15, Table S5, Supporting Information), supporting that reducing HIPK1, instead of completely suppressing it, was already sufficient to prevent pathological cardiac hypertrophy and cardiac dysfunction. This evidence concerns the gene HIPK1 and cardiac hypertrophy.