Based on the results of our study, we suggest that the aberrant methylation level of GABRA3 (gamma-aminobutyric acid (GABA) A receptor, subunit beta 3) and GABRA5 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha5) could play an important role in the MDS pathophysiology due to their impact through the GABAergic synapses. The gene discussed is GABRA5; the disease is myelodysplastic syndrome.