In addition, neutralizing CKLF1 greatly increased the phagocytosis of infiltrating neutrophils by microglia, as evidenced by an increase in the co-localization of microglia and neutrophils in the ischemic marginal zone (Fig. 8E), which provides evidence for the principal role of CKLF1 in the immune tolerance of microglia following stroke. Here, CKLF is linked to Stroke.