SDHB and renal cell carcinoma: (4) Succinate dehydrogenase-deficient renal cell carcinoma: It is mainly manifested by the lack of SDHB protein expression and SDH gene germline mutation; the microscopic features of tumor cells are a lobulated contour, pushing growth, a solid nest arrangement, cystic structure, rich cytoplasm, eosinophilic flocculation, and vacuolar appearance.