The results of this study revealed that compared with Roux-en-Y anastomosis, patients who underwent jejunal interposition after total gastrectomy had lower incidence of reflux esophagitis and dumping syndrome; higher prognostic nutritional index, postoperative hemoglobin, albumin, and total protein levels; and less changes in postoperative body mass; however, the operation time was relatively longer in the jejunal interposition group. The gene discussed is ALB; the disease is gastroesophageal reflux disease.