By progression to Epi-T4, the antigen processing and presenting pathway, the apoptotic pathway, the cellular senescence pathway, the cell adhesion molecule pathway, the NF-κB signaling pathway and the EBV infection pathway were inhibited, while the nucleotide metabolism pathway and the ribosome pathway were activated, especially the ribosome pathway was activated more significantly than in the above three periods (Fig. 5H). This evidence concerns the gene NFKB1 and Epstein-Barr virus infection.