CA2 and breast cancer: In Luminal A breast cancer, the cytosolic carbonic anhydrases CA1 (HR = 1.295, Additional file 1: Fig. S2A), CA2 (HR = 1.340, Additional file 1: Fig. S2B), and CA3 (HR = 0.753, Additional file 1: Fig. S2C) associate significantly with survival, and a similar influence of CA2 is observed in Luminal B breast cancer (HR = 1.205, Additional file 1: Fig. S3B).