Whereas high expression levels of extracellular carbonic anhydrases predict improved survival in HER2-enriched breast cancer (hazard ratio (HR) = 0.581, Fig. 3C), they associate with reduced survival in Basal-like breast cancer (HR = 1.541, Fig. 3D) and show no overall effect on survival in Luminal A (HR = 0.984, Fig. 3A) and Luminal B (HR = 1.064, Fig. 3B) breast cancer. The gene discussed is ERBB2; the disease is breast cancer.