APOE and dementia: These limitations concern the underestimation of alcohol use relative to per capita consumption [13, 14], inconsistent definitions of alcohol consumption patterns and abstinence [15], regression dilution bias due to measurement error when alcohol use is surveyed only once [12], and missing consideration of confounders, such as APOE4 genotype, education, and other known dementia risk factors such as smoking and physical inactivity [2].