CRIM1 and breast carcinoma: Given that genes can be regulated in trans by elements on other chromosomes [26], it is possible that somatic non-coding changes of distal regulatory elements can affect breast cancer progression by altering the levels and functions of SNRPD1. Thus, CRIM1, a gene located adjacent to the eQTL variant of SNRPD1 and known with a regulatory role on epithelial-mesenchymal transition (EMT) and lung cancer metastasis [27], may be responsible for the observed role of SNRPD1 on breast cancer cell migration.