IL24 and COVID-19: Our findings also offer insights into complex infectious and inflammatory diseases, which can cause secondary tissue damage, the proper repair of which is essential for disease tolerance and host survival.64,65 In this regard, it is intriguing that in severe COVID-19 cases, patients with damaged lungs display prominent IL-24,66 and the colons from patients with ulcerative colitis also express IL-24.49 Taken together, the implications of our findings here are likely to extend broadly to many conditions of tissue damage.