CD44V can bind with xCT to augment cystine influx into cytoplasm, leading to high concentration of intracellular cysteine, and tumor growth through cysteine transportation was demonstrated to play an important role in cancer stemness (cancer-initiation capacity) in the context of its NRF2 (NF-E2-related factor 2) association [11, 12]. This evidence concerns the gene NFE2L2 and cancer.