In recent years, blood and tumor ILC-1s have been defined in the literature based on transcript expression of CD3D, CD3G, CD3E, CCL5, GMK, GZMM, GZMA, BCL11B, PRDM1, IKZF3, EOMES, and TBET (41), along with protein expression consisting of IL-7Rpos, c-KITneg, and CRTH2neg subsets (42). Here, GUK1 is linked to neoplasm.