This Ben-PINK1-Parkin mediated Marf degradation in lrpprc2 appears to be a cell protective mechanism as lrpprc2 ben double mutants show accelerated retinal degeneration and worsened adult wing phenotype as compared to lrpprc2 mutant (Figs 9 and S9). This evidence concerns the gene GTF2IRD1 and retinal degeneration.