Moreover, the disease-specific subnetwork contains two thrombophilia-related genes present in the DisGeNet database, TGFB1 (transforming growth factor beta-1, TGFβ-1) and F12 (coagulation factor XII), which are both disease-specific variants (Fig 4, panels B and C). The gene discussed is TGFB1; the disease is Rare hereditary thrombophilia.