These neutrophils extrude oxidized nucleic acids that promote induction of type I interferons (IFNs; cytokines crucial in SLE pathogenesis) in target cells, primarily through the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway and/or through endosomal TLRs [18,19,24]. Here, CGAS is linked to systemic lupus erythematosus.