In addition, we also performed IF of macrophage markers on the transplanted tumor specimens of animals in each group, and the results showed that, compared with the control groups M2‐Exos or M2/sh‐NC‐Exos, the proportion of F4/80+CD206+ in the M2‐Exos+Annexin V or the M2/sh‐1232#1‐Exos group was significantly lower (Figure S4a, Supporting Information). Here, ANXA5 is linked to neoplasm.