CD8A and malignant colon neoplasm: reported that CC motif chemokine ligand 5 (CCL5) secreted by TAMs promotes colon cancer by inducing the deubiquitination and stability of the PD‐L1 protein in colon cancer cells and inhibiting CD8+ CTL‐mediated cell killing to promote cellular immune escape.[13] This evidence implies that TAM exosomes play an important role in tumor immune escape.