Studies have found that macrophages with PI3Kγ inactivation highly express MHC class II molecules and proinflammatory cytokines such as interleukin 12 (IL‐12), while they express low levels of the immunosuppressive molecules IL‐10, and Arginase, etc. In a series of tumor models, inhibition of the PI3Kγ‐mediated activity of TAMs can activate adaptive immunity, enhance the recruitment, and activity of cytotoxic T lymphocytes, and thus significantly inhibit cancer cell growth and metastasis. The gene discussed is IL10; the disease is cancer.