In addition, ELISA results indicated that CD8+ T‐cell supernatants cocultured with M2‐Exos‐cultured glioma cells had lower levels of IFN‐γ, TNF‐α, and Gzmb secretion; however, after adding the exosome inhibitor Annexin V or knocking down LINC01232, this phenomenon was reversed (Figure S3c, Supporting Information). This evidence concerns the gene ANXA5 and central nervous system cancer.