Recently, a study in Nature reported that adipose tissue exosomes can deliver miRNAs to regulate gene expression in distal tissues.[25] Our previous study showed that exosomes derived from glioma stem cells that carry Linc01060 promote glioma progression through the MZF1/c‐Myc/HIF1a signaling axis.[26] Herein, we cocultured M2 macrophages with tumor cells and showed that M2 macrophages can promote immune escape from tumors (Figure 1). The gene discussed is HIF1A; the disease is central nervous system cancer.