Interestingly, Donepezil (AChE enzyme inhibitor) increased ACh availability, lowering negative symptoms in PTSD patients, and also inhibited LPS-induced neuroinflammation via α7nAChRs, which is followed by the PI3K-Akt mechanism, and this pathway might serve as a reference for the emergence of new therapies for reversing neuroinflammation or offer new indications for existing treatments (Table 1) (Tyagi et al. 2010; Navarro et al. 2021; Prajapati and Krishnamurthy 2021). Here, AKT1 is linked to post-traumatic stress disorder.