CHAT and post-traumatic stress disorder: The cholinergic deficit has also been reported in the SRS-induced PTSD model in rodents, where donepezil ameliorated the SRS-induced cognitive inflexibility, downregulation of α7nAChR and expressed a reduced activity of choline acetyltransferase (ChAT) along with the increased activity of acetylcholine esterase (AChE) enzymes respectively (Prajapati and Krishnamurthy 2021).