SIRT1 induces deacetylation of helix loop helix transcription factor 2 (NHLH2) in the ventral CA1 region of the brain and enhances MAO-A transcription which then results in decomposition of serotonin (5HT) to 5 hydroxy indole acetic acid (5-HIAA) and influences PTSD-like moods and behaviors in SPS model of PTSD. The gene discussed is NHLH2; the disease is post-traumatic stress disorder.