AKT1 and post-traumatic stress disorder: Cotinine modulates synaptic plasticity and PTSD symptoms by stimulating downstream signaling of α7nAChR receptor; the protein kinase B (Akt)/glycogen synthase kinase 3β (GSK3β) pathway and ERKs (extracellular signal-regulated kinases) (Barreto et al. 2015; Mendoza et al. 2018).