For the primary melanoma cell line—WM3211 (VGP), with a wild type for BRAF, PTEN, N-RAS, and CDK4, and with a mutation at position 576 in the c-KIT gene, caspase 3 activation compared to the control was several times lower than for the metastatic lines Mel-1359 and MEWO (Figs. 3, 4 and 5a). Here, CDK4 is linked to melanoma.