However, our case 3 demonstrated malignant features such as myometrial extension and lymph node metastasis, without any desmin positivity and had CREM as partner for EWSR1. Indeed, the majority of intra-abdominal malignant epithelioid neoplasms do not express desmin and involve CREM as partner for ESWR1/FUS, while AFHs show diffuse desmin positivity with ESWR1/FUS::CREB1/ATF1 fusions, like our two first cases. The gene discussed is CREB1; the disease is metastatic malignant neoplasm in the lymph nodes.