TGFB1 and cancer: Among the downregulated pathways with IP expression, the hedgehog (Hh) signalling (n = 26), mitotic spindle (n = 25), UV response (n = 25), Wnt‐beta signalling (n = 23), TGF‐β signalling (n = 20) and G2M checkpoint genes (n = 17) were most frequent between the different cancer types (Fig. 4A).