ESCAT IV: non‐V600E BRAF mutations prevailed in right‐sided CRC (4.6% versus 1.4% in left‐sided CRC), like RNF43 (4.6% versus 2.1%), and contrary to FBXW7 mutations (9 out of 187, only observed in left‐sided CRC). Here, RNF43 is linked to colorectal carcinoma.