ANGPT2 and glaucoma: Interestingly, inactivation of Angpt1 and Angpt2 or Tie2 completely abolishes Schlemm’s canal development and leads to glaucoma formation in mice, while the Schlemm’s canal is still present and only reduced in mice lacking Vegfc and Vegfd or Vegfr3, indicating that in some lymphatic structures VEGFC is not strictly required (Bernier-Latmani and Petrova, 2017; Thomson and Quaggin, 2018).