Healthy breasts, hyperplasias, papillomas, and carcinomas in situ from 434 women [13]. ~10% of OPN-c pathology score 0–1 (intensity), vs. 40% of score 3 experience cancer over 5 years.>90% of women, who progress, had pathology scores of 2–3 for OPN-c intensity at the time of initial diagnosis.Combining OPN-c and OPN-exon-4 staining → all low intensity patients are alive after 5 years, women in the high category have a close to 30% chance to die.Of patients who succumb, close to 80% had a high combined score at initial diagnosis. This evidence concerns the gene SPP1 and cancer.