The results of TOP/FOP reporter assays using SW48 and SW480 cells, which carry APC and CTNNB1 mutations, respectively, treated with two independent VSNL1 siRNAs revealed that VSNL1 KD did not affect Wnt/β‐catenin signaling activity in CRC cells (Figure S8A). This evidence concerns the gene APC and colorectal carcinoma.