TSC2 and Familial prostate cancer: DNA damage‐inducible transcript 4 (DDIT4), variously termed REDD1 or RTP801, is induced by a variety of stress conditions, including oxidative stress, endoplasmic reticulum stress, hypoxia, and starvation.[42] Over the past decades, DDIT4 dysregulation has been observed in numerous human malignancies, such as prostate cancer, ovarian cancer, gastric cancer, and breast cancer.[24, 42] Moreover, DDIT4 inhibits mammalian target of rapamycin complex 1 (mTORC1) by stabilizing the tuberous sclerosis complex (TSC1–TSC2).