Consistent with our results, DDIT4‐AS1 promoted the stability of DDIT4 mRNA in the progress of E. coli infection.[17] However, contrary to our results, the overexpressed DDIT4‐AS1 in PDAC recruits UPF1 to destabilize DDIT4 mRNA.[35] We consider that the regulation of DDIT4 by DDIT4‐AS1 may be inconsistent due to the different types of pathologic conditions and the different intermediate regulatory proteins. The gene discussed is DDIT4; the disease is escherichia coli infection.