Consistent with our results, DDIT4‐AS1 promoted the stability of DDIT4 mRNA in the progress of E. coli infection.[17] However, contrary to our results, the overexpressed DDIT4‐AS1 in PDAC recruits UPF1 to destabilize DDIT4 mRNA.[35] We consider that the regulation of DDIT4 by DDIT4‐AS1 may be inconsistent due to the different types of pathologic conditions and the different intermediate regulatory proteins. This evidence concerns the gene UPF1 and escherichia coli infection.