For instance, the histone deacetylase HDAC2 could inhibit lncRNA H19 expression by histone H3K27 deacetylation in its promoter via binding with SP1.[39] Oct4, a key stemness transcription factor, transcriptionally activates lncRNA NEAT1 via promoter and lncRNA MALAT1 via enhancer binding to promote cell proliferation and motility, and led to lung tumorigenesis and poor prognosis.[40] Here, we found high enrichment of H3K27ac at the promoter of DDIT4‐AS1 in TNBC cell lines and tumor tissues, and the H3K27ac of DDIT4‐AS1 is positively associated with its expression. The gene discussed is SP1; the disease is neoplasm.