At the end point, BLI examination, postmortem H&E, and ISH/IHC staining of the liver or lung, along with CTCs quantification, showed that the enhanced proliferation and metastasis of orthotopic HCC induced by miR‐3190‐enriched EVs were restored by ectopic expression of ALKBH5 in orthotopic HCC cells (Figure 5F–I and Figure S8A, Supporting Information). The gene discussed is ALKBH5; the disease is hepatocellular carcinoma.