LCK and hepatocellular carcinoma: HCC‐LM3 (LM3) and its bone‐metastasized progeny LM3‐BM4 (BM4) cells were transduced with lentivirus carrying a lymphocyte protein tyrosine kinase‐green fluorescent protein(Lck‐GFP) transgene to generate GFP+ EVs.[24] Transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blot analysis confirmed the typical structure, size, and biomarkers of the secreted EVs both in wild‐type (WT) and in Lck‐GFP transduced HCC cells (LM3/Lck‐GFP and BM4/Lck‐GFP) (Figure1A–C).