also found that ALKBH5 acted as a tumor suppressor in HCC formation and progression by facilitating the degradation of LYPD1, NCBI Gene ID: 116372, full name: LY6/PLAUR domain containing 1 via m6A modification.[21] However, ALKBH5 was also reported to promote HCC progression by forming a positive‐feedback loop with Hepatitis B Virus X protein, and recruiting programmed cell death ligand 1+ macrophage infiltration.[22] Interestingly, besides its function as an m6A eraser, Zhu et al. Here, CD274 is linked to hepatocellular carcinoma.