LCAT and hepatocellular carcinoma: The decreased level of LCAT led to the disruption of bone homeostasis and exacerbated liver fibrosis by restraining the transport of cholesterol from the bone to the liver.[12] In HCC, low preoperative bone mineral density was found to be an independent risk factor for HCC mortality after surgery.[13] However, the effect of the bone‐liver axis on the outcome and progression of patients with HCC and bone metastasis remains unclear.