GFP signals were detected in orthotopic HCC cells in mice with BM4/Lck‐GFP sh‐NC cells, but not in the other groups, indicating Lck‐GFP‐EVs secreted by bone‐metastasized HCC (HCC‐BM) cells were taken up by orthotopic HCC cells (Figure 1G,H). Here, LCK is linked to hepatocellular carcinoma.