Further analysis regarding left‐ and right‐sided CRC revealed no significant difference (p = 0.09) in OS between left‐ and right‐sided CRCs with DDR mutations (Figure 4C), whereas left‐sided CRC patients with HRR pathway mutations that were relatively independent of the KRAS mutation (p = 0.211), had a significantly prolonged OS compared with right‐sided CRC (p = 0.0091) (Figure 4D). This evidence concerns the gene KRAS and colorectal carcinoma.