Currently, the main CSC markers found to be associated with CRC are CD133, CD29, CD166, CD44, Lgr5, oct4, Nanog, etc.38, 39, 40, 41These stem cell markers are involved in proliferation, invasive metastasis, and drug resistance of CRC via multiple molecular mechanisms.38, 39. The gene discussed is PROM1; the disease is colorectal carcinoma.