To examine how SMC1A modulates the immune microenvironment in COAD, we first investigated the expression of SMC1A at the single‐cell levels in different cell types using the TISCH (Tumor Immune Single‐cell Hub) (http://tisch.comp‐genomics.org/home/; http://tisch.comp‐genomics.org/home/) database, and we found that SMC1A was highly expressed in many types of immune cells among several datasets (Figure 3A). The gene discussed is SMC1A; the disease is colon adenocarcinoma.